A new publication of F. Devaux Team in NAR:The discovery of novel specific ribosome-associated factors challenges the assumption that translation relies on standardized molecular machinery. In this work, we demonstrate that Tma108, an uncharacterized translation machinery-associated factor in yeast, is a specific nascent-chain associated factor selectively recruited during the translation of less than 200 mRNAs encoding proteins with ATP or Zinc binding domains. Tma108 is a unique example of a nascent chain-associated factor with high selectivity and its study illustrates the existence of other specific translation-associated factors besides RNA binding proteins.To the article