The paper "Combined collapse by bridging and self-adhesion in a prototypical polymer model inspired by the bacterial nucleoid"from the Genomic Phisics was selected for the cover page on the journal Soft Matter, 8, 2015.
Nitric oxyde oxydases are enzymes which contributes to the resistance of pathogenic microbes to the innate immune system by detoxifying nitric oxide. "The genetic networks" team identified a new regulator of the expression of nitric oxydases in fungi and deciphered its functioning and evolution in different pathogenic and non-pathogenic yeast species. http://www.ncbi.nlm.nih.gov/pubmed/25732006
A. Gillet-Markowska, H. Richard, G. Fischer & I. Lafontaine just published a new tool - Ulysses - providing an accurate detection of low-frequency structural variations in large insert-size sequencing libraries. Ulysses is a valuable tool for the characterization of somatic mosaicism in human tissues and in cancer genomes.Ulysses: accurate detection of low-frequency structural variations in large insert-size sequencing librariesBioinformatics 2014; doi: 10.1093/bioinformatics/btu730
The "Biology of Genomes" team and the "Intraspecific Variation and Genome Evolution" team from the Université de Strasbourg have published the first population genomics survey in a yeast different form a Saccharomyces species. This study reveals that consequently to a large-scale introgression event, two different mutational regimes can coexist within the same genome.
Alice Coucke, Eleonora De Leonardis and Matteo Figliuzzi (Statistical Genomics Group) and Vittore Scolari (Genomic Physics Group) co-organize the 2nd edition of the conference:Paris Biological Physics Community Day 2014The conference will be held at Centre Culturel Irlandais in Paris
The Biology of Genomes team participated to the complete design and synthesis of the first eukaryotic synthetic chromosome. We compared replication dynamics of synthetic and native chromosome III and saw few dramatic changes in spite of several autonomously replicating sequences having been deleted.Total Synthesis of a Functional Designer Eukaryotic Chromosome. Annaluru, Muller et al., Science (2014) DOI:10.1126/science.1249252
A World Community Grid Lecture Series webcast describing the work done by the team and its collaborators on protein-protein interactions, within the framework of the “Help Cure Muscular Dystrophy” project can be found here.
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