The Biology of Genomes team participated to the complete design and synthesis of the first eukaryotic synthetic chromosome. We compared replication dynamics of synthetic and native chromosome III and saw few dramatic changes in spite of several autonomously replicating sequences having been deleted.
The first eukaryotic synthetic chromosome
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Occurrence of deletions, associated with genetic instability in Streptomyces ambofaciens, is independent of the linearity of the chromosomal DNA.
Phylogenetic reconstruction based on synteny block and gene adjacencies.
Université Paris-Cité PhD- Léo Minglu Li
