Analytical Genomics

Computational approach

A novel computational approach of coevolution analysis allowed us to reconstruct the protein-protein interaction network of the Hepatitis C Virus at the residue resolution. For the first time, coevolution analysis of an entire viral genome was realized. Champeimont R, Laine E, Hu S-W, Penin F, Carbone A. Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins. Scientific Reports.

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9 May 2016

Analytical Genomics / Article / Biology of Genomes / News

Complete reconstruction of genome history

We achieved the complete reconstruction of genome history in a model yeast genus, providing a granular view of genome evolution linking gene content, chromosome rearrangements and protein divergence into a single evolutionary framework.N Vakirlis, Sarilar V, G Drillon, A Fleiss, N Agier, J-P Meyniel, L Blanpain, A Carbone, H Devillers, K Dubois, A Gillet-Markowska, S Graziani, Nguyen H-V, M Poirel, C Reisser, J Schott, J Schacherer, I Lafontaine, B Llorente, C Neuvéglise and Fischer G. Reconstruction of ancestral chromosome architecture and gene repertoire reveals principles of genome evolution in a model yeast genus. Genome Research (2016).

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13 April 2016

Analytical Genomics / Article / Diatom Genomics / News / Statistical Genomics and Biological Physics

Diatom Phytochromes

A.E. Fortunato, M. Jaubert, J.P. Bouly, M. Thaler and A. Falciatore from the Diatom Functional Genomics team in collaboration with J.S. Bernardes (Statistical Genomics and Biological Physics), A. Carbone (Analytical Genomics) and other international collaborators published on The Plant Cell the paper “Diatom Phytochromes Reveal the Existence of Far-Red-Light-Based Sensing in the Ocean.” Full text paper.Plant Cell Editor’s comment on this work.

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1 March 2016

Analytical Genomics / Publications

Local Geometry and Evolutionary Conservation of Protein Surfaces Reveal the Multiple Recognition Patches in Protein-Protein Interactions.

Laine E., Ripoche H., Carbone A. Biophysical Journal (2016)

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1 February 2016

Analytical Genomics / News

new large-scale method to predict protein-protein

E.Laine and A.Carbone just published a new large-scale method to predict protein-protein interfaces based on sequence and structure information - Joint Evolutionary Trees 2 (JET2). It is the first time that a method highlights, with such a precision, information on distinguished binding sites, possibly overlapping each other.To the Article and Software.

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1 January 2016

Analytical Genomics / Publications