The many types of heterogeneity in replicative senescence
Xu Z., Teixeira M. Yeast (2019)
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1 November 2019
Molecular characterization of Chlamydomonas reinhardtii telomeres and telomerase mutants
Eberhard S., Valuchova S., Ravat J., Fulneček J., Jolivet P., Bujaldon S., Lemaire S., Wollman F., Teixeira M., Riha K., Xu Z. Life Science Alliance (2019)
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1 June 2019
Adaptation in replicative senescence: a risky business.
Coutelier H., Xu Z. Current Genetics (2019)
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1 June 2019
A subtelomeric region affects telomerase-negative replicative senescence in Saccharomyces cerevisiae
Jolivet P., Serhal K., Graf M., Eberhard S., Xu Z., Luke B., Teixeira M. Scientific Reports (2019)
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12 February 2019
Telomere and Genome Stability
The latest publication of the new LCQB team "Telomere and Genome Stability" (Héloïse Coutelier and Zhou Xu) makes the cover of the December issue of Genes & Development! The article (Coutelier et al. 2018 Genes Dev.) shows that telomere-induced senescent cells can adapt to the DNA damage checkpoint safeguard mechanism to force cell division, leading to increased genome instability, with important ramifications for aging and cancer. The cover displays cells bearing a fluorescent reporter construct monitoring of the checkpoint status in single cells.
6 December 2018
Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability.
Coutelier H., Xu Z., Morisse M., Lhuillier-Akakpo M., Pelet S., Charvin G., Dubrana K., Teixeira M. Genes & Development (2018)
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1 December 2018
Effects of initial telomere length distribution on senescence onset and heterogeneity.
Eugène S., Bourgeron T., Xu Z. Journal of Theoretical Biology (2017)
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1 January 2017