Tma108, a putative M1 aminopeptidase, is a specific nascent chain-associated protein in Saccharomyces cerevisiae.

Delaveau T., Davoine D., Jolly A., Vallot A., Rouvière J., Gerber A., Brochet S., Plessis M., Roquigny R., Merhej J., Leger T., Garcia C., Lelandais G., Laine E., Palancade B., Devaux F., Garcia M. Nucleic Acids Research (2016)

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Transcriptional regulatory networks

F. Devaux's team published one of the first ChIP-seq-based description of the transcriptional regulatory networks in the pathogenic yeast Candida glabrata. This work, which was performed in collaboration with J-M. Camadro and G. Lelandais from the Jacques Monod Institute and with the NGS platform directed by S. Le Crom, is the first publication from a larger ANR project aiming at a comprehensive description of stress response regulatory networks in this emerging human pathogen.

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The resistance of pathogenic microbes

Nitric oxyde oxydases are enzymes which contributes to the resistance of pathogenic microbes to the innate immune system by detoxifying nitric oxide. "The genetic networks" team identified a new regulator of the expression of nitric oxydases in fungi and deciphered its functioning and evolution in different pathogenic and non-pathogenic yeast species. http://www.ncbi.nlm.nih.gov/pubmed/25732006

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