The Biology of Genomes team participated to the complete design and synthesis of the first eukaryotic synthetic chromosome. We compared replication dynamics of synthetic and native chromosome III and saw few dramatic changes in spite of several autonomously replicating sequences having been deleted.

Total Synthesis of a Functional Designer Eukaryotic Chromosome. Annaluru, Muller et al., Science (2014) DOI:10.1126/science.1249252